Once upon a time, I attempted to create a web-based one-stop-shop for global poverty relief called the Maximin Project. Drawing on aspects of that experience, I show that although some existing ways of rating and recommending charities are significantly better than others, there remain certain challenges that need to be overcome. Specifically, I argue that the emerging Effective Altruism movement, with its emphasis on measurable effectiveness, runs the risk of neglecting a whole range of projects that are necessary for a (...) well-rounded approach to human development. I briefly model an alternative virtue-based approach that calls on the personal insight of individual researchers and practitioners in addition to the more directly experimental approach of organizations like GiveWell. (shrink)

In this paper, we discuss a team-taught, debate-style Philosophy of Religion course we designed and taught at The Ohio State University. Rather than tackling the breadth of topics traditionally subsumed under the umbrella of Philosophy of Religion, this course focused exclusively on the nuances of the atheism-theism debate, with the instructors openly identifying as atheist or theist, respectively. After discussing the motivations for designing and teaching such a course, we go on to detail its content and structure. We then examine (...) various challenges and hurdles we faced, as well as some benefits we encountered along the way. Next, we discuss some informal data collected from the students enrolled in the course, some of which suggest some rather surprising outcomes. We conclude with some considerations of the applicability of this style of teaching to other philosophical debates. (shrink)

Somatic mutations arising in human skin cancers are heterogeneously distributed across the genome, meaning that certain genomic regions (e.g., heterochromatin or transcription factor binding sites) have much higher mutation densities than others. Regional variations in mutation rates are typically not a consequence of selection, as the vast majority of somatic mutations in skin cancers are passenger mutations that do not promote cell growth or transformation. Instead, variations in DNA repair activity, due to chromatin organization and transcription factor binding, have been (...) proposed to be a primary driver of mutational heterogeneity in melanoma. However, as discussed in this review here, recent studies indicate that chromatin organization and transcription factor binding also significantly modulate the rate at which UV lesions form in DNA. The authors propose that local variations in lesion susceptibility may be an important driver of mutational hotspots in melanoma and other skin cancers, particularly at binding sites for ETS transcription factors. (shrink)

This introduction to the Common Knowledge symposium titled “Comparative Relativism” outlines a variety of intellectual contexts where placing the unlikely companion terms comparison and relativism in conjunction offers analytical purchase. If comparison, in the most general sense, involves the investigation of discrete contexts in order to elucidate their similarities and differences, then relativism, as a tendency, stance, or working method, usually involves the assumption that contexts exhibit, or may exhibit, radically different, incomparable, or incommensurable traits. Comparative studies are required to (...) treat their objects as alike, at least in some crucial respects; relativism indicates the limits of this practice. Jensen argues that this seeming paradox is productive, as he moves across contexts, from Lévi-Strauss's analysis of comparison as an anthropological method to Peter Galison's history of physics, and on to the anthropological, philosophical, and historical examples offered in symposium contributions by Barbara Herrnstein Smith, Eduardo Viveiros de Castro, Marilyn Strathern, and Isabelle Stengers. Comparative relativism is understood by some to imply that relativism comes in various kinds and that these have multiple uses, functions, and effects, varying widely in different personal, historical, and institutional contexts that can be compared and contrasted. Comparative relativism is taken by others to encourage a “comparison of comparisons,” in order to relativize what different peoples—say, Western academics and Amerindian shamans—compare things “for.” Jensen concludes that what is compared and relativized in this symposium are the methods of comparison and relativization themselves. He ventures that the contributors all hope that treating these terms in juxtaposition may allow for new configurations of inquiry. (shrink)

BackgroundCritical public health measures implemented to mitigate the spread of the novel coronavirus disease (COVID-19) pandemic have disrupted health research worldwide, including HIV prevention research. While general guidance has been issued for the responsible conduct of research in these challenging circumstances, the contours of the dueling COVID-19 and HIV/aids pandemics raise some critical ethical issues for HIV prevention research. In this paper, we use the recently updated HIV Prevention Trials Network (HPTN) Ethics Guidance Document (EGD) to situate and analyze key (...) ethical challenges related to the conduct of HIV prevention research during the COVID-19 pandemic as well as identify potential areas for refinement of the guidance document based on this unprecedented state of affairs.Main bodyNecessary actions taken for HIV prevention research studies due to the COVID-19 pandemic involve an array of ethical issues including those related to: (1) risk mitigation; (2) behavior change; (3) compounding vulnerability; (4) community engagement; (5) trial reopening; and 6) shifting research priorities.ConclusionsIn the context of the dueling HIV and COVID-19 global pandemics, research teams and sponsors must be nimble in responding to the rapidly changing environment by being sensitive to the associated ethical issues. The HTPN EGD provides a rich set of tools to help identify, analyze and address many of these issues. At the same time, future refinements of the HPTN EGD and other research ethics guidance could be strengthened by providing explicit advice regarding the ethical issues associated with disrupted research and the reopening of studies. In addition, additional consideration should be given to appropriately balancing domains of risk (e.g., physical versus social), addressing the vulnerability of research staff and community partners, and responding to un-anticipatable ancillary care needs of participants and communities. Appropriately addressing these issues will necessitate conceptual work, which would benefit from the careful documentation of the actual ethical issues encountered in research, the strategies implemented to overcome them, and their success in doing so. Throughout all of these efforts, it is critical to remember that the HIV pandemic not be forgotten in the rush to deal with the COVID-19 pandemic. (shrink)

In ancient times, when persuasion played the role of public force, eloquence was necessary. Of what use would it be today, when public force has replaced persuasion. One needs neither art nor metaphor to say such is my pleasure. Jean Jacques Rousseau.

This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Biomedical Informatics: We Are What We Publish", written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by an editorial. This article contains the combined commentaries invited to independently comment on the Elkin et al. paper. In subsequent issues the discussion can continue through letters to the editor.

Mark Blaug's contributions to economics were many and significant. This essay provides a review of Mark Blaug: Rebel with Many Causes, edited by Marcel Boumans and Matthias Klaes, which collects papers from a set of conferences organized in Blaug's memory.

This paper presents three theses on the kind of human kinds represented by masculinity and femininity: (1) Genders are taken to be generic realities, (2) complementary kinds of a kind, and (3) normative and valid organizations of intention in community. Analogies are considered between gender and temperament, culture, race, age, and sexual orientation.

Hooks are the particular elements in works of art that are in fact specially compelling for individual subjects. Hooks have their own kind of aesthetic meaningfulness that is obscured by the calculations of cultural manipulators, on the one hand, and by leading aesthetic theories’ insistence upon subordinating parts of a work to the whole, on the other. Hook appreciation inspires desirable adjustments in those theories.

Why should past occurrences matter to us as such? Are they in fact meaningful in a specifically historical way, or do they only become meaningful in being connected to other sorts of meaning—political or speculative, for example—as many notable theorists imply? Ranke and Oakeshott affirmed a purely historical meaningfulness but left its nature unclear. The purpose of this essay is to confirm historical meaningfulness by arguing that our commanding practical interest in how we share action with other actors is distinctively (...) engaged by presumed information about past occurrences. We recognize that past occurrences have determined the conditions of action sharing, constraining our practice with regard to which actors we share practical reality with and which compounding actions we may or must join in progress. (shrink)

“Intrinsic value” is a perplexing notion in that it purports to establish a relationship with a thing that cannot in fact be established by the valuing subject butcan only be welcomed. An important sense of “good” expresses the non-axiological side of shared flourishing. We do need the concept of intrinsic value to put our different kinds of value in order, but we can also recognize that the positing of intrinsic value is grounded on events of appeal wherein perceived beings promise (...) distinctive forms of benign partnership with their perceivers. The ideal of appeal maximalism can displace the problematic ideal of unrestricted intrinsic value as a basis for expanding the circle of moral consideration. (shrink)

This book illuminates the aesthetically underrated meaningfulness of particular elements in works of art and aesthetic experiences generally. Beginning from the idea of "hooks" in popular song, the book identifies experiences of special liveliness that are of enduring interest, supporting contemplation and probing discussion. When hooks are placed in the foreground of aesthetic experience, so is an enthusiastic “grabbing back” by the experiencer who forms a quasi-personal bond with the beloved singular moment and is probably inclined to share this still-evolving (...) realization of value with others. This book presents numerous models of enthusiastic “grabbing back” that are art-critically motivated to explain how hooks achieve their effects and philosophically motivated to discover how hooks and hook appreciation contribute to a more ideally desirable life. Framing hook appreciation with a defensible general model of aesthetic experience, this book gives an unprecedented demonstration of the substantial aesthetic and philosophical interest of hook-centered inquiry. (shrink)

A historically responsible agent is willing to be somehow in practical solidarity with all other actors with whom action is shared over time. The responsible idea of a most-inclusive history encompasses future occurrence together with all that has happened already. Despite our lack of control over future developments, we assess possible future ages as bright or dark and position ourselves as contributors to multigenerational endeavors that we hope will be long-term successes in themselves and part of a larger historical optimality. (...) Informed by the evolutionary sciences, a plausible modern envisioning of the future must include evolutionary innovations and surprises on a very long time scale. The historically responsible agent will therefore take seriously efforts like Olaf Stapledon’s Last and First Men to imagine the new powers and goals of our distantly posthuman future sharers in history. (shrink)

The history of economic thought has always attracted some of the brightest minds in the discipline. These chroniclers of development have helped form our current views, and it is no surprise that many among them have been at the forefront of new movements in the history of ideas. This notable collection summarizes the work of these key historians of economics and attempts to quantify their impact. Some of the writers covered, such as Friedrich Hayek and Joan Robinson, are already assured (...) of their place among the greatest economists of the twentieth century, but the collection also stresses the influence of those still active in shaping our perceptions - including Mark Blaug, Samuel Hollander and Donald Winch. Written by an impressive roster of contributors, many of whom are themselves well-known in the history of economic thought, this key book features writings from John Creedy, Roger Blackhouse and Neil De Marchi, as well as the editors of the collection as a whole, Warren J. Samuels and Steven Medema. (shrink)

If the mental is subject to indeterminacy, does this rule out the possibility of psychophysical laws? One might think so. However, Jaegwon Kim has argued for the existence of a kind of psychophysical law that is not obviously susceptible to problems posed by indeterminacy. I begin by introducing a weak and relatively uncontroversial indeterminacy thesis. Then, by appealing to constraints on theories of strong supervenience and to general considerations about the nature of indeterminacy, I argue that even Kim’s laws cannot (...) accommodate indeterminacy. The result is an argument against the possibility of Kim‐Style psychophysical laws. (shrink)

The transactivation response‐DNA binding protein of 43 kDa (TDP‐43) is an aggregation‐prone nucleic acid‐binding protein linked to the etiology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). These conditions feature the accumulation of insoluble TDP‐43 aggregates in the neuronal cytoplasm that lead to cell death. The dynamics between cytoplasmic and nuclear TDP‐43 are altered in the disease state where TDP‐43 mislocalizes to the cytoplasm, disrupting Nuclear Pore Complexes (NPCs), and ultimately forming large fibrils stabilized by the C‐terminal prion‐like (...) domain. Here, we review three emerging and poorly understood aspects of TDP‐43 biology linked to its aggregation. First, how post‐translational modifications in the proximity of TDP‐43 N‐terminal domain (NTD) promote aggregation. Second, how TDP‐43 engages FG‐nucleoporins in the NPC, disrupting the pore permeability and function. Third, how the importin α/β heterodimer prevents TDP‐43 aggregation, serving both as a nuclear import transporter and a cytoplasmic chaperone. (shrink)

"To my knowledge, there has never [before] been a volume that analyzes, in one place, the actual language of science--those elements of thinking that are acknowledged to be the basis of scientific thought. . . . [Thus] this is a very important book, contributing to several fields: science, education, rhetoric, medicine, and perhaps even philosophy. . . . Darian's erudition is truly astonishing." --Celest A. Martin, Associate Professor, College Writing Program, University of Rhode Island From astronomy to zoology, the practice (...) of science proceeds from scientific ways of thinking. These patterns of thought, such as defining and classifying, hypothesizing and experimenting, form the building blocks of all scientific endeavor. Understanding how they work is therefore an essential foundation for everyone involved in scientific study or teaching, from elementary school students to classroom teachers and professional scientists. In this book, Steven Darian examines the language of science in order to analyze the patterns of thinking that underlie scientific endeavor. He draws examples from university science textbooks in a variety of disciplines, since these offer a common, even canonical, language for scientific expression. Darian identifies and focuses in depth on nine patterns--defining, classifying, using figurative language, determining cause and effect, hypothesizing, experimenting, visualizing, quantifying, and comparing--and shows how they interact in practice. He also traces how these thought modes developed historically from Pythagoras through Newton. (shrink)

An original metaphysical proposal building on classical and contemporary sources. In Centering and Extending, Steven G. Smith retrieves and refashions some of the best ideas of classical and early modern metaphysics to support insight into the natures of mental and material beings and their relations. Avoiding what he critiques as distortive paths of idealism, materialism, repressive monism, and overly permissive pluralism, Smith builds his framework on centering and extending as universal principles of formation. Identifying the basic consistency of being (...) with these principles in symmetrical partnership enables a naturalist process view that, unlike Whitehead’s, does not overbalance toward the subjective and teleological and, unlike Deleuze and Guattari’s, does not overbalance toward the material and chaotic. This view supports useful conceptions of mind and matter, form and energy, reason and cause, and a layered world order without relying on a blind concept of supervenience or emergence. It also respects and reinforces a division of roles between metaphysical sense-making and spiritual determinations of meaningfulness. Steven G. Smith is Jennie Carlisle Golding Professor of Philosophy at Millsaps College. He is the author of several books, including Worth Doing, also published by SUNY Press. (shrink)

I argue that Gold & Stoljar's “trivial neuron doctrine” is not in fact trivial. Many familiar positions in the philosophy of mind run afoul of it, and it is unclear that even those whom Gold & Stoljar identify as adherents of the trivial neuron doctrine can be comfortably described as such.

In this book, Steven G. Smith focuses on the guidance function in language and scripture and evaluates the assumptions and ideals of scriptural religion in global perspective. He brings to language studies a new pragmatic emphasis on the shared modeling of life-in-the-world by communicators constantly depending on each other's guidance. Using concepts of axiality and axialization derived from Jaspers' description of the 'Axial Age', he shows the essential role of scripture in the historical progress of communicative action. This volume (...) clarifies the formative power of scriptures in religions of the 'world religion' type and brings scripture into philosophy of religion as a major cross-cultural category of study, thereby helping philosophy of religion find a needed cross-cultural footing. (shrink)

Some of kant's rationales for conceiving the highest good of morality as virtue rewarded with happiness rest on the subject's "necessary" natural desire for happiness, While others appeal to a still-Obscure principle of moral desert. The principle, I argue, Is that the moral agent qua moral necessarily hopes for the "approval" of fellow moral legislators and god, Who "would" (did they exist, And if they could) signify their approval by bestowing the means of happiness.

ABSTRACT Ken Hanly's recent article in this Journal (Vol. 9, No. 1, 1992) takes issue with Ronald Coase's approach to resolving problems of externalities, as set forth in his classic paper ‘The Problem of Social Cost’. I argue that Hanly's discussion of Coase misinterprets or inappropriately rejects certain aspects of Coase's analysis, specifically, with regard to the reciprocal nature of externalities and the economic role of government. The resolution of externality problems is presented as an issue of selective normative choice (...) as to whose interests are to count; neither efficiency nor morality claims are uniquely dispositive of the issue. (shrink)

This essay examines the logic of greatness attributions in general and the implications of aesthetic positions taken by Hume, Shelley, and T. M. Greene in order to show how the attitude of faith, i.e. a disposition for unbounded personal growth, can constitute greatness in experiences or in objects or occasions of experience. On this basis the role of great experiences in education is elucidated. It is argued that faith takes a distinctively free aesthetic form in the educational frame of reference (...) so that great experiences may abound. (shrink)

This paper uses the humor of Road Runner cartoons as a test of our intuitions about causality as these intuitions are appealed to by the rival theories of Hume and Kant. I argue that Road Runner cartoons are funnier to Kantians, with their stronger presumption of necessary causal regularity, and therefore supportive of Kantianism to the degree that we find this humor compelling.

This paper revives the idea of final cause as a way of considering how the meaning of occurrences--what they have permitted in our lives, as opposed to what produced them or how they fit into a prior plan--is essential to our understanding them.

Argues against a consumption-oriented vision of agents' relation with material things that there are worthy, morally happy kinds of owner-partnership with things and that expansion of access to owner worth should be among the goals of moral, political, and economic policy.

A concept of merit is used for spiritual accounting in many religious traditions, seemingly a substantial point of connection between religion and ordinary morality. Teachings of “merit transfer” (as in Buddhism and Roman Catholicism) might make us doubt this connection since they violate the principle that merit must be earned. If we examine the structure of ordinary schemes of desert, however, we find that personal worth is posited for a variety of reasons; the basic requirement in this realm is not (...) earning by individuals but rather a community’s program for cultivating desirable collaboration among its members. There are strong enough parallels between religiously envisioned merit transfer and socially normal conferrals and sharings of worth that we can conclude that the religious posits of transferred merit are indeed comprehensible as merit, whatever other problems of comprehensibility they pose. (shrink)